Rabbit Hole: Droperidol in Acute Agitation

Droperidol

Edge R, Argáez C. Droperidol for Agitation in Acute Care [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2021 Jan. PMID: 34185452.

Khokhar MA, Rathbone J. Droperidol for psychosis-induced aggression or agitation. Cochrane Database Syst Rev. 2016 Dec 15;12(12):CD002830. doi: 10.1002/14651858.CD002830.pub3. PMID: 27976370; PMCID: PMC6463952.

Chan EW, Taylor DM, Knott JC, Phillips GA, Castle DJ, Kong DC. Intravenous droperidol or olanzapine as an adjunct to midazolam for the acutely agitated patient: a multicenter, randomized, double-blind, placebo-controlled clinical trial. Ann Emerg Med. 2013 Jan;61(1):72-81. doi: 10.1016/j.annemergmed.2012.07.118. Epub 2012 Sep 13. PMID: 22981685.

Yap CYL, Taylor DM, Knott JC, Taylor SE, Phillips GA, Karro J, Chan EW, Kong DCM, Castle DJ. Intravenous midazolam-droperidol combination, droperidol or olanzapine monotherapy for methamphetamine-related acute agitation: subgroup analysis of a randomized controlled trial. Addiction. 2017 Jul;112(7):1262-1269. doi: 10.1111/add.13780. Epub 2017 Feb 28. PMID: 28160494.

Taylor DM, Yap CYL, Knott JC, Taylor SE, Phillips GA, Karro J, Chan EW, Kong DCM, Castle DJ. Midazolam-Droperidol, Droperidol, or Olanzapine for Acute Agitation: A Randomized Clinical Trial. Ann Emerg Med. 2017 Mar;69(3):318-326.e1. doi: 10.1016/j.annemergmed.2016.07.033. Epub 2016 Oct 10. PMID: 27745766.

Rosen CL, Ratliff AF, Wolfe RE, Branney SW, Roe EJ, Pons PT. The efficacy of intravenous droperidol in the prehospital setting. J Emerg Med 1997;15:13–7.

Calver L, Drinkwater V, Gupta R, Page CB, Isbister GK. Droperidol v. haloperidol for sedation of aggressive behaviour in acute mental health: randomised controlled trial. Br J Psychiatry. 2015 Mar;206(3):223-8. doi: 10.1192/bjp.bp.114.150227. Epub 2014 Nov 13. PMID: 25395689.

Thomas H Jr, Schwartz E, Petrilli R. Droperidol versus haloperidol for chemical restraint of agitated and combative patients. Ann Emerg Med. 1992 Apr;21(4):407-13. doi: 10.1016/s0196-0644(05)82660-5. PMID: 1554179.

Calver L, Isbister GK. High dose droperidol and QT prolongation: analysis of continuous 12-lead recordings. Br J Clin Pharmacol. 2014 May;77(5):880-6. doi: 10.1111/bcp.12272. PMID: 24168079; PMCID: PMC4004408.

Perkins J, Ho JD, Vilke GM, DeMers G. American Academy of Emergency Medicine Position Statement: Safety of Droperidol Use in the Emergency Department. J Emerg Med. 2015 Jul;49(1):91-7. doi: 10.1016/j.jemermed.2014.12.024. Epub 2015 Mar 30. PMID: 25837231.

Calver L, Page CB, Downes MA, Chan B, Kinnear F, Wheatley L, Spain D, Isbister GK. The Safety and Effectiveness of Droperidol for Sedation of Acute Behavioral Disturbance in the Emergency Department. Ann Emerg Med. 2015 Sep;66(3):230-238.e1.

Review Article

Dundar Y, Greenhalgh J, Richardson M, Dwan K. Pharmacological treatment of acute agitation associated with psychotic and bipolar disorder: a systematic review and meta-analysis. Hum Psychopharmacol. 2016 Jul;31(4):268-85. doi: 10.1002/hup.2535. Epub 2016 May 5. PMID: 27151529.
Bak M, Weltens I, Bervoets C, De Fruyt J, Samochowiec J, Fiorillo A, Sampogna G, Bienkowski P, Preuss WU, Misiak B, Frydecka D, Samochowiec A, Bak E, Drukker M, Dom G. The pharmacological management of agitated and aggressive behaviour: A systematic review and meta-analysis. Eur Psychiatry. 2019 Apr;57:78-100. doi: 10.1016/j.eurpsy.2019.01.014. Epub 2019 Feb 2. PMID: 30721802.
Kim HK, Leonard JB, Corwell BN, Connors NJ. Safety and efficacy of pharmacologic agents used for rapid tranquilization of emergency department patients with acute agitation or excited delirium. Expert Opin Drug Saf. 2021 Feb;20(2):123-138. doi: 10.1080/14740338.2021.1865911. Epub 2021 Jan 13. PMID: 33327811.