Rapid Sequence Intubation (RSI): Rocuronium For RSI
Mechanism of Action
- Rocuronium is a nondepolarizing NMBA that acts as a competitive inhibitors of acetylcholine (ACh) receptors.
- Nondepolarizing NMBAs bind to the ACh receptor without causing a conformational change which would tradionally allow passage of sodium ions.
- Rocuronium is monoquaternary steroid analogue of vecuronium designed to provide a rapid onset of action
- 1 to 1.2 (commonly 1) mg/ kg total body weight IV
- In obese patients ideal body weight (IBW) or total body weight (TBW) may be used
Lower doses have been studied (<1 mg/kg), however, the onset of action with lower dosages isn’t ideal for emergent intubations such as RSI.
- IV: 45-90 seconds
- Larger doses lead to quicker onset of action
- 30-90 minutes
- Larger doses leads to more prolonged duration of action
- Minimally hepatically
- Renal Excretion: Feces (31%); urine (26%)
- Very few reported, but possible increased peripheral vascular resistance (abdominal aortic surgery)
- Allergy to class/drug
The main problem with high dose nondepolarizing neuromuscular blocking agents is prolonged recovery time
If a patient needs to have frequent neurological assessments soon after intubation, reversal of rocuronium could be considered with a neostigmine + atropine or sugammadex.
Have post-intubation sedation plan set prior to intubation to minimized awake paralysis
|Author, year||Design/ sample size||Intervention & Comparison||Outcome|
|Noninferiority randomized clinical trial|
|Succinylcholine ≥ 1.5 mg/kg|
Rocuronium ≥ 1.2 mg/kg
|Successful first-attempt intubation was 455 of 610 (74.6%) in the rocuronium group vs 489 of 616 (79.4%) in the succinylcholine group, with a between-group difference of -4.8% (1-sided 97.5% CI, -9% to ∞), which did not meet criteria for noninferiority.|
|Succinylcholine ≥ 1 mg/kg|
Rocuronium ≥ 1.2 mg/kg
|The first-pass intubation success rate was no different between the agents with 87.0% with succinylcholine versus 87.5% with rocuronium (adjusted OR 0.9; 95% CI 0.6- 1.3|
|Succinylcholine (dosing not reported)|
Rocuronium (dosing not reported)
|In the high-severity TBI patients, succinylcholine was associated with increased mortality compared with rocuronium (OR 4.10, 95% CI 1.18–14.12).|
|Succinylcholine 1.7 ± 0.7 mg/kg|
Rocuronium 1.3 ± 0.4 mg/kg
|After intubation, 77.5% (n=155) of patients were initiated on a sedative infusion of propofol (n=148) or midazolam (n=7).|
Mean time to post-intubation sedation was significantly greater with rocuronium compared to succinylcholine (27 min vs 15; p <0.001)
| Succinylcholine (dosing not reported)|
Rocuronium (dosing not reported)
|No difference in oxygen desaturations between succinylcholine and rocuronium (P = .67)|
|Succinylcholine or |
|Onset time of rocuronium 0.9 mg/kg and 1.2 mg/kg rocuronium and succinylcholine (1 mg/kg) were similar; onset times for rocuronium 0.6 mg/kg and vecuronium (0.1 mg/kg) were much longer|
Comments by ED Physician Attendings
|” Has reversal agent, not associated with malignant|
hyperthermia, not associated with hyperkalemia (no
fasciculation), dosed on ideal body weight (100mg will
give 1.2 mg/kg for male that is 6’4)”
|” Longer paralytic time, however has reversal agent”|
- Guihard B, Chollet-Xémard C, Lakhnati P, et al. Effect of Rocuronium vs Succinylcholine on Endotracheal Intubation Success Rate Among Patients Undergoing Out-of-Hospital Rapid Sequence Intubation: A Randomized Clinical Trial. JAMA. 2019;322(23):2303-2312. doi:10.1001/jama.2019.18254
- April MD, Arana A, Pallin DJ, Schauer SG, Fantegrossi A, Fernandez J, Maddry JK, Summers SM, Antonacci MA, Brown CA 3rd; NEAR Investigators. Emergency Department Intubation Success With Succinylcholine Versus Rocuronium: A National Emergency Airway Registry Study. Ann Emerg Med. 2018 Dec;72(6):645-653. doi: 10.1016/j.annemergmed.2018.03.042. Epub 2018 May 7. PMID: 29747958.
- Tran DTT, Newton EK, Mount VAH, Lee JS, Mansour C, Wells GA, Perry JJ. Rocuronium vs. succinylcholine for rapid sequence intubation: a Cochrane systematic review. Anaesthesia. 2017 Jun;72(6):765-777. doi: 10.1111/anae.13903. PMID: 28654173.
- Patanwala AE, Erstad BL, Roe DJ, Sakles JC. Succinylcholine Is Associated with Increased Mortality When Used for Rapid Sequence Intubation of Severely Brain Injured Patients in the Emergency Department. Pharmacotherapy. 2016 Jan;36(1):57-63. doi: 10.1002/phar.1683. PMID: 26799349.
- Patanwala AE, Stahle SA, Sakles JC, Erstad BL. Comparison of succinylcholine and rocuronium for first-attempt intubation success in the emergency department. Acad Emerg Med. 2011 Jan;18(1):10-4. doi: 10.1111/j.1553-2712.2010.00954.x. Epub 2010 Dec 23. PMID: 21182564.
- Weiss JH, Gratz I, Goldberg ME, Afshar M, Insinga F, Larijani G. Double-blind comparison of two doses of rocuronium and succinylcholine for rapid-sequence intubation. J Clin Anesth. 1997 Aug;9(5):379-82. doi: 10.1016/s0952-8180(97)00065-2. PMID: 9257203.
- Smith CE, Kovach B, Polk JD, Hagen JF, Fallon WF Jr. Prehospital tracheal intubating conditions during rapid sequence intubation: rocuronium versus vecuronium. Air Med J. 2002 Jan-Feb;21(1):26-32. doi: 10.1067/mmj.2002.121713. PMID: 11805764.
- Magorian T, Flannery KB, Miller RD. Comparison of rocuronium, succinylcholine, and vecuronium for rapid-sequence induction of anesthesia in adult patients. Anesthesiology. 1993 Nov;79(5):913-8. doi: 10.1097/00000542-199311000-00007. PMID: 7902034.
- Micromedex [Electronic version].Greenwood Village, CO: Truven Health Analytics. Retrieved September 6, 2018, from http://www.micromedexsolutions.com/