Corticosteroids in Sepsis by Marissa Marks, PharmD
Introduction Pharmacology Hydrocortisone Methylprednisolone Fludrocortisone Dose IV: 50 mg Q6H or 100 mg Q8H x 5-7 days IV (succinate): 40 to 125 mg/day (maximum…
Category: Pharmacy Friday Pearls
Etomidate for RSI: Seizure Considerations
Introduction Rapid sequence intubation (RSI) is a process whereby an induction agent and a neuromuscular blocking agent are given in rapid succession to facilitate endotracheal…
Ketamine for Treatment of Acute Agitation
Introduction Ketamine is a sedative used for patients with extreme/refractory undifferentiated agitation Indications for utilizing ketamine for emergent sedation of agitated patients include Patient poses…
PPIs for the Management of Upper GI Bleed
Introduction Upper GI bleed (UGIB) is a common reason for ED visits with a major cause of morbidity, mortality and medical care costs. Peptic ulcer…
Concomitant Parenteral Benzodiazepines and Olanzapine
Introduction Intramuscular olanzapine and parenteral benzodiazepines are commonly used agents in the ED for acute agitation. An FDA warning states that potentially fatal respiratory depression…
Alteplase for Acute Ischemic Stroke
Introduction Alteplase (rt-PA) has been used for acute ischemic stroke since its approval by the FDA in 1996 after publication of promising results of…
Hypertonic Saline Versus Mannitol for ICP Reduction
Introduction Elevated intracranial pressure (ICP) is caused by excess volume in the cerebral spaces, which causes a reduction in the cerebral perfusion pressure and…
Fosphenytoin vs Keppra for Status Epilepticus
Introduction Status epilepticus is a neurological emergency that required urgent assessment and treatment with pharmacologic agents Lorazepam and diazepam are short-acting drugs that can produce…
Management of Hypertensive Emergency
Introduction Hypertensive emergency is characterized by systolic blood pressure (SBP) > 180 mmHg or diastolic blood pressure (DBP) > 120 mmHg with evidence of target…
Fibrinolytics for STEMI
Introduction Percutaneous coronary intervention (PCI) is the preferred reperfusion strategy during a cardiac arrest; thrombolytic therapy is an option without PCI capability, followed by transfer…