Corticosteroids in Sepsis by Marissa Marks, PharmD
Introduction Pharmacology Hydrocortisone Methylprednisolone Fludrocortisone Dose IV: 50 mg Q6H or 100 mg Q8H x 5-7 days IV (succinate): 40 to 125 mg/day (maximum…
Introduction Pharmacology Hydrocortisone Methylprednisolone Fludrocortisone Dose IV: 50 mg Q6H or 100 mg Q8H x 5-7 days IV (succinate): 40 to 125 mg/day (maximum…
Introduction Rapid sequence intubation (RSI) is a process whereby an induction agent and a neuromuscular blocking agent are given in rapid succession to facilitate endotracheal…
Introduction Ketamine is a sedative used for patients with extreme/refractory undifferentiated agitation Indications for utilizing ketamine for emergent sedation of agitated patients include Patient poses…
Introduction Upper GI bleed (UGIB) is a common reason for ED visits with a major cause of morbidity, mortality and medical care costs. Peptic ulcer…
Introduction Intramuscular olanzapine and parenteral benzodiazepines are commonly used agents in the ED for acute agitation. An FDA warning states that potentially fatal respiratory depression…
Introduction Alteplase (rt-PA) has been used for acute ischemic stroke since its approval by the FDA in 1996 after publication of promising results of…
Introduction Elevated intracranial pressure (ICP) is caused by excess volume in the cerebral spaces, which causes a reduction in the cerebral perfusion pressure and…
Introduction Status epilepticus is a neurological emergency that required urgent assessment and treatment with pharmacologic agents Lorazepam and diazepam are short-acting drugs that can produce…
Introduction Hypertensive emergency is characterized by systolic blood pressure (SBP) > 180 mmHg or diastolic blood pressure (DBP) > 120 mmHg with evidence of target…
Introduction Percutaneous coronary intervention (PCI) is the preferred reperfusion strategy during a cardiac arrest; thrombolytic therapy is an option without PCI capability, followed by transfer…